Acetone → HCID 88456076, compound

HRID 1708512Notes

Reaction equation

HRID 1708512 reaction equation
[BrH:1].[NH2:2][CH:3]1[C:15](=[O:16])[N:5]2[C:6]([C:12]([OH:14])=[O:13])=[C:7]([CH3:11])[CH2:8][S:9](=[O:10])[C@H:4]12.[CH3:17][C:18]([CH3:20])=O>C(O)(=O)C>[Br-:1].[C:12]([C:6]1[N:5]2[C:15](=[O:16])[CH:3]([NH+:2]=[C:18]([CH3:20])[CH3:17])[C@H:4]2[S:9](=[O:10])[CH2:8][C:7]=1[CH3:11])([OH:14])=[O:13]

Participants

5

Reactant 3

HCID 180AcetoneHCID 260Hydrogen BromideHCID 67841623HCID 67841623, compound

Product 1

HCID 88456076HCID 88456076, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

With stirring 0.4 ml of a hydrogen bromide solution (33%) in acetic acid was added to 1 g (2.1 mmoles) of 7-amino-3-methyl-1-oxo-3-cephem-4-carboxylic acid at 0° C. After adding gradually 5 ml of acetone a crystalline precipitate was obtained, which was filtered off, washed with acetone and dried giving 0.60 g (79%) of the title product.

Workup

  1. customwas obtained
  2. filtrationwhich was filtered off
  3. washwashed with acetone
  4. customdried

Sources & evidence

ORD record
ord-0b8f5e4bc5f74fb296d7660f4d22f45b
Source dataset
uspto-grants-1994_10
Patent number
US05359058

Reaction notes

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