反应详情

A solution of ethyl 1-[N-(hydroxymethyl)-N-methylamino]-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (8.4 g) and triethylamine (3.09 g) in methylene chloride (150 ml) was cooled to 0° C. and treated with acetyl chloride (2.18 g). After 3 hours the reaction was diluted with water and shaken in a separating funnel. The organic layer was dried over magnesium sulfate, evaporated, and the crude product purified by chromatography with silica gel (50% ethyl acetate-hexane elution) to yield ethyl 1-[N-(ethoxymethyl)-N-methylamino]-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (2.1 g).

1. dry with materialThe organic layer was dried over magnesium sulfate
2. customevaporated
3. customthe crude product purified by chromatography with silica gel (50% ethyl acetate-hexane elution)