Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 15232659 | HCID 15232659 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 15232662 | HCID 15232662 | 93.2% |
Reaction Steps
The compound (1.4 g) of Example 4 was dissolved into 10% aqueous solution of sodium hydroxide (30 ml) and small quantity of ethanol and the solution was refluxed at 80° C. for 2 hours under heat. After cooling, this was acidified with concentrated hydrochloric acid. The crystals deposited were collected by filtration and recrystallized from ethanol-hexane to obtain aimed product (1.2 g) as pale yellow prismatic crystals. Melting point: 127°-129° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05359076 |
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| Source dataset | uspto-grants-1994_10 |
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| ORD ID | ord-c1488e22c43c474bb573d92f1970f46b |
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| Source note | uspto-grants-1994_10 |
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