Hydrochloric Acid → HCID 15232662, compound

HRID 1708571Notes

Reaction equation

HRID 1708571 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:19][C:20]([O:22]CC)=[O:21])[CH:5]=[C:6]2[C:11]=1[NH:10][CH:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[F:18])[CH2:8][CH2:7]2.[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:19][C:20]([OH:22])=[O:21])[CH:5]=[C:6]2[C:11]=1[NH:10][CH:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[F:18])[CH2:8][CH2:7]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15232659HCID 15232659, compound

Product 1

HCID 15232662HCID 15232662, compoundYield 93.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

The compound (1.4 g) of Example 4 was dissolved into 10% aqueous solution of sodium hydroxide (30 ml) and small quantity of ethanol and the solution was refluxed at 80° C. for 2 hours under heat. After cooling, this was acidified with concentrated hydrochloric acid. The crystals deposited were collected by filtration and recrystallized from ethanol-hexane to obtain aimed product (1.2 g) as pale yellow prismatic crystals. Melting point: 127°-129° C.

Workup

  1. temperatureunder heat
  2. temperatureAfter cooling
  3. filtrationThe crystals deposited were collected by filtration
  4. customrecrystallized from ethanol-hexane

Sources & evidence

ORD record
ord-c1488e22c43c474bb573d92f1970f46b
Source dataset
uspto-grants-1994_10
Patent number
US05359076

Reaction notes

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