反应详情

A mixture of 40.0 grams (0.123 mol) of N-(1-octyloxy-2,2,6,6-tetramethylpiperidin-4-yl) acetamide and 6N hydrochloric acid is heated at reflux for three hours. The reaction mixture is cooled and extracted with 2×150 ml). The aqueous layer is made basic and extracted with 3:1 ether:dichloromethane (3×150 ml). The three organic extracts are combined, dried over anhydrous magnesium sulfate and then concentrated to an oil. Purification by Kugelrohr distillation at 110°-120° C./0.5 mm affords 28.9 grams (83% yield) of the title compound as a pale yellow oil.

1. temperatureis heated
2. temperatureat reflux for three hours
3. temperatureThe reaction mixture is cooled
4. extractionextracted with 2×150 ml)
5. extractionextracted with 3:1 ether
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated to an oil
8. customPurification
9. distillationby Kugelrohr distillation at 110°-120° C./0.5 mm