反应详情

Sodium hydride (0.7 g. 5.9 mmol) is added to a solution of 17.0 g (59.5 mmol) of 1-(1-octyloxy--2,2,6,6-tetramethylpiperidin-4-yloxy)-2,3-epoxypropane (prepared in Example 11) in 75 ml of dioxane. The reaction mixture is heated at reflux for 10 minutes and then cooled to 60° C., whereupon a solution of 10.0 g (29.3 mmol) of 4-hydroxy-1-octyloxy-2,2,6,6-tetramethylpiperidine (prepared in Example 5) in 25 ml of dioxane is rapidly added. The reaction mixture is heated at reflux for 4 hours, treated with an additional 0.6 g of sodium hydride, and heated at reflux for 7 hours. The reaction mixture is diluted with diethyl ether (500 ml), and the organic solution is washed with 1N hydrochloric acid (2×100 ml) and saturated sodium bicarbonate solution, dried over magnesium sulfate, and concentrated to an oil. Purification by flash chromatography on silica gel (9:1 heptane: ethyl acetate) affords 8.4 g (46% yield) of the title compound, a colorless oil.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 10 minutes
3. additionis rapidly added
4. temperatureThe reaction mixture is heated
5. temperatureat reflux for 4 hours
6. temperatureheated
7. temperatureat reflux for 7 hours
8. washthe organic solution is washed with 1N hydrochloric acid (2×100 ml) and saturated sodium bicarbonate solution
9. dry with materialdried over magnesium sulfate
10. concentrationconcentrated to an oil
11. customPurification by flash chromatography on silica gel (9:1 heptane: ethyl acetate)