Hydroxide → [4-(4-Amino-2-fluorophenoxy)pyridin-2-yl]-N-(phenoxycarbonyl)carbamic acid phenyl ester

HRID 170867Notes

Reaction equation

HRID 170867 reaction equation
[O:45]1[CH2:46][CH2:47][CH2:48][CH2:49]1.[OH-:50].[OH-:52].[Pd+2:51].[c:1]1([O:7][C:8]([N:9]([C:10](=[O:11])[O:12][c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[c:19]2[n:20][cH:21][cH:22][c:23]([O:25][c:26]3[c:27]([F:43])[cH:28][c:29]([NH:32][C:33]([O:34][CH2:35][c:36]4[cH:37][cH:38][cH:39][cH:40][cH:41]4)=[O:42])[cH:30][cH:31]3)[cH:24]2)=[O:44])[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([O:7][C:8]([N:9]([C:10](=[O:11])[O:12][c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[c:19]2[n:20][cH:21][cH:22][c:23]([O:25][c:26]3[c:27]([F:43])[cH:28][c:29]([NH2:32])[cH:30][cH:31]3)[cH:24]2)=[O:44])[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

5

Reactant 4

HCID 961Hydroxide2×HCID 8028TetrahydrofuranHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 59597005{4-[4-(Benzyloxycarbonylamino)-2-fluorophenoxy]pyridin-2-yl}-N-(phenoxycarbonyl)carbamic acid phenyl ester

Product 1

HCID 59596934[4-(4-Amino-2-fluorophenoxy)pyridin-2-yl]-N-(phenoxycarbonyl)carbamic acid phenyl ester

Sources & evidence

ORD record
ord-d213d5cb3112480590d35425b478487b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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