HRID1708796

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：COC(OC)C(C)[C@H]1CC[C@H]2[C@@H]3C=C[C@@]4(O)C[C@@H](O)C[C@H](O)[C@]4(C)[C@H]3CC[C@]12C

HCID57085412

未命名化合物

反应SMILES：CC(=O)O[C@H]1C[C@H](O)[C@]2(C)[C@H]3CC[C@]4(C)[C@@H](C(C)C5OCCO5)CC[C@H]4[C@@H]3C=C[C@@]2(O)C1

HCID67852965

未命名化合物

PRODUCTS

产物

反应SMILES：CC(=O)O[C@H]1C[C@H](OC(=O)c2ccccc2)[C@]2(C)[C@H]3CC[C@]4(C)[C@@H](C(C)C5OCCO5)CC[C@H]4[C@@H]3C=C[C@@]2(O)C1

HCID67852961

未命名化合物

收率 92.8%

PROCEDURE

实验过程

The reaction and workup procedures of Example 105 were repeated except that 350 mg of 20-(1,3-dioxolan-2-yl)-3β-acetoxypregn-6-ene-1α,5α-diol was used in lieu of 400 mg of 21,21-dimethoxy-20-methylpregn-6-ene-1α,3β,5α-triol to give 400 mg of 20-(1,3-dioxolan-2-yl)-3β-acetoxy-1α-benzoyloxypregn-6-en-5α-ol showing the following physical properties.

WORKUP

后处理

customThe reaction and workup procedures of Example 105

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-99bebc4f970d4b75985bf65e3295ae74
来源数据集: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05359055
来源说明: uspto-grants-1994_10

反应SMILES

[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH:6]([C@@H:8]1[C@:25]2([CH3:26])[C@H:11]([C@H:12]3[C@H:22]([CH2:23][CH2:24]2)[C@:20]2([CH3:21])[C@:15]([OH:32])([CH2:16][C@@H:17]([O:28][C:29](=[O:31])[CH3:30])[CH2:18][C@@H:19]2[OH:27])[CH:14]=[CH:13]3)[CH2:10][CH2:9]1)[CH3:7].COC(OC)C(C)[C@@H]1[C@]2(C)[C@H]([C@H:41]3[C@H:51](CC2)[C@:49]2(C)[C@:44](O)(C[C@@H](O)C[C@@H:48]2[OH:56])[CH:43]=[CH:42]3)CC1>>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH:6]([C@@H:8]1[C@:25]2([CH3:26])[C@H:11]([C@H:12]3[C@H:22]([CH2:23][CH2:24]2)[C@:20]2([CH3:21])[C@:15]([OH:32])([CH2:16][C@@H:17]([O:28][C:29](=[O:31])[CH3:30])[CH2:18][C@@H:19]2[O:27][C:48](=[O:56])[C:49]2[CH:51]=[CH:41][CH:42]=[CH:43][CH:44]=2)[CH:14]=[CH:13]3)[CH2:10][CH2:9]1)[CH3:7]