HCID 15036876, compound → 6-Fluoropyridine-2-sulfonamide

HRID 1708840Notes

Reaction equation

HRID 1708840 reaction equation
CC([NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[N:10]=1)(=[O:8])=[O:7])(C)C>FC(F)(F)C(O)=O>[F:15][C:11]1[N:10]=[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])[CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 1

HCID 15036876HCID 15036876, compound

Product 1

HCID 150368776-Fluoropyridine-2-sulfonamideYield 82.1%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

To 100 ml trifluoroacetic acid was added 11.6 g (50 mmol) of N-(1,1-dimethylethyl)-6-fluoro-2-pyridinesulfonamide and the mixture was refluxed for two days. The volatiles were then removed in vacuo and the residue triturated with ether to afford 7.23 g of tan solid, m.p. 110° C. to 111° C.

Workup

  1. temperaturethe mixture was refluxed for two days
  2. customThe volatiles were then removed in vacuo
  3. customthe residue triturated with ether

Sources & evidence

ORD record
ord-3ac2bf274d4a476aa7fc14f40f03caa0
Source dataset
uspto-grants-1990_08
Patent number
US04946494

Reaction notes

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