Methylamine → HCID 15036878, compound

HRID 1708841Notes

Reaction equation

HRID 1708841 reaction equation
[CH3:1][NH2:2].F[C:4]1[N:9]=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:7]=[CH:6][CH:5]=1>>[CH3:1][NH:2][C:4]1[N:9]=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 150368776-Fluoropyridine-2-sulfonamide

Product 1

HCID 15036878HCID 15036878, compound

Procedure

To 10 ml of condensed methylamine was added 1.86 g (10 mmol) of 6-fluoropyridine-2-sulfonamide. The mixture was allowed to reflux under a dry-ice condenser for 4 hr, then excess amine was allowed to evaporate overnight. The residue was crystallized with water to yield 1.64 g of tan solid, m.p. 124° C. to 126° C. NMR (CDCl3): δ 2.64 (s, 3H), 6.12 (br s, 2H), 6.30 (d, 1H), 6.86 (d, 1H), 7.23 (dd, 1H).

Workup

  1. temperatureto reflux under a dry-ice condenser for 4 hr
  2. customto evaporate overnight
  3. customThe residue was crystallized with water

Sources & evidence

ORD record
ord-41059be2bc364f7cb466ed724b32bc13
Source dataset
uspto-grants-1990_08
Patent number
US04946494

Reaction notes

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