Pyrazole → 1-(2,4,6-Trichlorophenyl)-3-acetylamino-4-pyrazolyl-5-oxo-2pyrazoline

Participants

Reaction Conditions

Reaction Steps

Next, 57 g (0.15 mol) of the 1-(2,4,6-trichlorophenyl)-3-acetylamino-4-bromo-5-oxo-2-pyrazoline and 41 g of pyrazole (0.6 mol) were mixed well, then heated for 6 hours at 75° C. in a stream of nitrogen gas to react, after which the reaction mixture was cooled to room temperature. Next the reaction mixture was dissolved in ethyl acetate and the solution was washed with water three times and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, acetonitrile was added to the residual oil, and the deposited crystals were filtered to obtain 20.1 g (34.7%) of 1-(2,4,6-trichlorophenyl)-3-acetylamino-4-pyrazolyl-5-oxo-2pyrazoline.

Provenance & Evidence