Hydrochloric Acid → HCID 178509129, compound

HRID 1708855Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14](=[O:15])[CH:13]([C:16]2[CH:20]=[CH:19][NH:18][N:17]=2)[C:12]([NH:21]C(=O)C)=[N:11]1.Cl.[OH-].[K+].O>C(O)C.CO>[NH2:21][C:12]1[CH:13]([C:16]2[CH:20]=[CH:19][NH:18][N:17]=2)[C:14](=[O:15])[N:10]([C:3]2[C:4]([Cl:9])=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[N:11]=1

Participants

Conditions

Temperature: 10 °C

Procedure

Next, 31 g (0.08 mol) of the 1-(2,4,6-trichlorophenyl)-3-acetylamino-4-pyrazolyl-5-oxo-2-pyrazoline in 600 ml of ethanol was heated under reflux while 55 ml of concentrated hydrochloric acid was added. Then, after 1 hour, the reaction mixture was cooled to about 10° C. and neutralized with a solution containing 39 g of potassium hydroxide in 400 ml of methanol. The resulting solution was added to 2.5 l of water to obtain 21.6 g (78%) of 3-amino-1-(2,4,6-trichlorophenyl)-4-pyrazolyl-5-oxo-2-pyrazoline.

Workup

additionwas added

Sources & evidence

ORD record: ord-d325ccbe0bf942a6884084c4528ae49f
Source dataset: uspto-grants-1990_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04946771

Reaction notes

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