4-(3-Chloropropyl)-1,2-dimethoxybenzene → 1-Ethyl-4-(3,4-dimethoxyphenyl)-1-(2-thienyl)butyl isocyanide

HRID 1708970Notes

Reaction equation

HRID 1708970 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]([N+:9]#[C-:10])[CH2:7][CH3:8].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH2:21][CH2:22][CH2:23]Cl)[CH:16]=[CH:17][C:18]=1[O:19][CH3:20]>>[CH2:7]([C:6]([N+:9]#[C-:10])([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[CH2:23][CH2:22][CH2:21][C:15]1[CH:16]=[CH:17][C:18]([O:19][CH3:20])=[C:13]([O:12][CH3:11])[CH:14]=1)[CH3:8]

Participants

3

Reactant 2

HCID 148354334-(3-Chloropropyl)-1,2-dimethoxybenzeneHCID 152885881-(2-Thienyl)propyl isocyanide

Product 1

HCID 230390181-Ethyl-4-(3,4-dimethoxyphenyl)-1-(2-thienyl)butyl isocyanideYield 68.3%

Procedure

4.84 g of 1-(2-thienyl)propyl isocyanide and 6.87 g of 3-(3,4-dimethoxyphenyl)propyl chloride are treated in the same manner as described in Example 1-(1) to give 7.2 g of 1-ethyl-4-(3,4-dimethoxyphenyl)-1-(2-thienyl)butyl isocyanide as a colorless oil. Yield; 68.3%

Sources & evidence

ORD record
ord-52da1e5f37a74dc390ac211c892163cb
Source dataset
uspto-grants-1990_08
Patent number
US04946862

Reaction notes

Loading…