1-Chloro-4-(3-chloropropyl)benzene → 1-Ethyl-4-(4-chlorophenyl)-1-(2-thienyl)butyl isocyanide

HRID 1708971Notes

Reaction equation

HRID 1708971 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]([N+:9]#[C-:10])[CH2:7][CH3:8].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][CH2:20]Cl)=[CH:14][CH:13]=1>>[CH2:7]([C:6]([N+:9]#[C-:10])([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[CH2:20][CH2:19][CH2:18][C:15]1[CH:16]=[CH:17][C:12]([Cl:11])=[CH:13][CH:14]=1)[CH3:8]

Participants

3

Reactant 2

HCID 27357201-Chloro-4-(3-chloropropyl)benzeneHCID 152885881-(2-Thienyl)propyl isocyanide

Product 1

HCID 230390121-Ethyl-4-(4-chlorophenyl)-1-(2-thienyl)butyl isocyanideYield 56.7%

Procedure

5.44 g of 1-(2-thienyl)propyl isocyanide and 6.81 g of 3-(4-chlorophenyl)propyl chloride are treated in the same manner as described in Example 1-(1) to give 6.2 g of 1-ethyl-4-(4-chlorophenyl)-1-(2-thienyl)butyl isocyanide as a colorless oil. yield; 56.7%

Sources & evidence

ORD record
ord-c6568685711a4cab89cf7aed986d0161
Source dataset
uspto-grants-1990_08
Patent number
US04946862

Reaction notes

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