反应详情

3-Chloro-4,5-dipropargyloxybenzaldehyde (14.7 g) was added to a solution of sodium borohydride (3.6 g) in ethanol (150 ml) at a temperature below 30° C. After stirring at room temperature for 2 hours, the resultant mixture was poured into dilute hydrochloric acid under cooling and extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate and concentrated under reduced pressure to give 3-chloro-4,5-dipropargyloxybenzyl alcohol (15.60 g). nD17.0 1.5713.

1. temperatureunder cooling
2. extractionextracted with ethyl acetate
3. washThe extract was washed with water
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated under reduced pressure