Lawesson's reagent → HCID 23036992, compound

HRID 1709098Notes

Reaction equation

HRID 1709098 reaction equation
[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[C:13](=O)[NH:12][CH2:11]2)(=[O:5])=[O:4].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:25])=CC=1>C1(C)C(C)=CC=CC=1>[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[C:13](=[S:25])[NH:12][CH2:11]2)(=[O:5])=[O:4]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 23036994HCID 23036994, compound

Product 1

HCID 23036992HCID 23036992, compoundYield 84.8%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A mixture of 0.68 g of N-methylisoindolin-1-one-7-sulfonamide, 0.61 g of Lawesson's reagent (2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide) and 15 ml of xylene was heated to reflux under nitrogen for 24 hours. The mixture was allowed to cool, the solid products collected, and recrystallized from isopropanol (carbon) to give 0.31 g of the title compound as a yellow solid, m.p. 231°-232° C.

Workup

  1. temperaturewas heated
  2. temperatureto reflux under nitrogen for 24 hours
  3. temperatureto cool
  4. customthe solid products collected
  5. customrecrystallized from isopropanol (carbon)

Sources & evidence

ORD record
ord-d8e4a1fd9ae145f99cc6514c316efb1a
Source dataset
uspto-grants-1990_08
Patent number
US04948416

Reaction notes

Loading…