Triethylamine → 7-Chloro-2,3-dihydro-4-isocyanato-2-methylbenzofuran

HRID 1709123ノート

反応式

HRID 1709123 の反応式
C(N(CC)CC)C.[NH2:8][C:9]1[C:14]2[CH2:15][CH:16]([CH3:18])[O:17][C:13]=2[C:12]([Cl:19])=[CH:11][CH:10]=1.Cl[C:21](OC(Cl)(Cl)Cl)=[O:22]>O1CCOCC1>[Cl:19][C:12]1[C:13]2[O:17][CH:16]([CH3:18])[CH2:15][C:14]=2[C:9]([N:8]=[C:21]=[O:22])=[CH:10][CH:11]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 10426DiphosgeneHCID 536714607-Chloro-2-methyl-2,3-dihydrobenzofuran-4-amine

生成物 1

HCID 537184027-Chloro-2,3-dihydro-4-isocyanato-2-methylbenzofuran

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

6.07 g of triethylamine was added to a mixture of 9.18 g of 32A, 11.87 g of trichloromethyl chloroformate and 250 mL of dioxane, and the mixture was refluxed for 6 hours. The mixture was cooled, filtered, and the filtrate was stripped of solvent, to give 7-chloro-2,3-dihydro-4-isocyanato-2-methylbenzofuran (34A), as a brown liquid.

後処理

  1. temperaturethe mixture was refluxed for 6 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-29f66627685a4cd4a4b6da6a2c40a95a
出典データセット
uspto-grants-1990_08
特許番号
US04948418

反応ノート

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