p-Anisoyl chloride → HCID 53674212, compound

Participants

Reaction Steps

11.2 cm3 of a 1.6M solution of n-butyllithium in n-hexane is added at -40° C. to a solution, cooled to -45° C., of 2.8 g of 5-n-butyloxy pyrrolidin-2-one in 70 cm3 of tetrahydrofuran with agitation for 30 minutes. Under the same conditions, a solution of 5.24 g of anisoyl chloride (at 58% in toluene) in 6 cm3 of tetrahydrofuran is added. After agitation for 2 hours, allowing to return to ambient temperature, the mixture is evaporated to dryness. The oil obtained is chromato-graphed on silica (eluent: toluene-ethyl acetate 8-2) and 2 g of the product sought is obtained.

Provenance & Evidence