反应详情

16.5 cm3 of a 15% solution butyllithium in hexane is added at -60° C. to 4.98 g of 5-n-heptyloxy pyrrolidin-2-one in solution in 100 cm3 of tetrahydrofuran. After 20 minutes of agitation at -60° C., 3.5 g of benzoyl chloride in 25 cm3 of tetra-hydrofuran is added at this temperature. Agitation is carried out for 4 hours, allowing the mixture to return to ambient temperature. After concentration at 40° C., the residue is taken up in water, extracted with ether and concentrated to dryness. The residue is chromatographed on silica (eluent: toluene-ethyl acetate 8-2) and 1.2 g of the product sought is obtained.

1. waitAgitation is carried out for 4 hours
2. customto return to ambient temperature
3. concentrationAfter concentration at 40° C.
4. extractionextracted with ether
5. concentrationconcentrated to dryness
6. customThe residue is chromatographed on silica (eluent: toluene-ethyl acetate 8-2) and 1.2 g of the product
7. customsought is obtained