2-Pentanol → 5-(2-Pentyloxy) pyrrolidin-2-one

HRID 1709192Notes

Reaction equation

HRID 1709192 reaction equation
[OH:1][CH:2]1[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1.[CH3:8][CH:9](O)[CH2:10][CH2:11][CH3:12]>>[CH3:8][CH:9]([O:1][CH:2]1[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1)[CH2:10][CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 223862-PentanolHCID 1941485-Hydroxy-2-pyrrolidone

Product 1

HCID 156965595-(2-Pentyloxy) pyrrolidin-2-one

Procedure

5.5 g of 5-hydroxy-pyrrolidin-2-one, 30 cm3 of 2-pentanol and 2.75 g of Amberlite-15 resin are agitated for 5 hours at ambient temperature. After filtering, the excess pentanol is distilled off under 1 mm Hg at 40° C. The residue is chromatograp:hed on silica, (eluent: ethyl acetate), and 3.7 g of the expected product is obtained.

Workup

  1. filtrationAfter filtering
  2. distillationthe excess pentanol is distilled off under 1 mm Hg at 40° C

Sources & evidence

ORD record
ord-06372e83e5ee4b958af715510c9327d2
Source dataset
uspto-grants-1990_08
Patent number
US04948804

Reaction notes

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