Neopentyl alcohol → HCID 15696561, compound

HRID 1709193Notes

Reaction equation

HRID 1709193 reaction equation
[CH3:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].C(O[CH:10]1[NH:14][C:13](=[O:15])[CH2:12][CH2:11]1)C>>[CH2:3]([O:4][CH:10]1[NH:14][C:13](=[O:15])[CH2:12][CH2:11]1)[C:2]([CH3:6])([CH3:5])[CH3:1]

Participants

3

Reactant 2

HCID 6404Neopentyl alcoholHCID 35805555-Ethoxy-2-pyrrolidinone

Product 1

HCID 15696561HCID 15696561, compoundYield 40.2%

Procedure

35 g 2,2-dimethyl propanol (previously melted at 45° C.), 6 g of 5-ethoxy pyrrolidin-2-one and 3 g of Amberlite-15 resin are agitated at 40° C. for 2 hours 15 minutes. After filtering, the 2,2-dimethyl propanol is distilled off under 0.8 mm/Hg at 35° C. The residue is dissolved in hexane and iced for 2 hours. 3.2 g of the expected product is obtained, m.p. 67°-69° C., crystallized from hexane.

Workup

  1. filtrationAfter filtering
  2. distillationthe 2,2-dimethyl propanol is distilled off under 0.8 mm/Hg at 35° C
  3. dissolutionThe residue is dissolved in hexane

Sources & evidence

ORD record
ord-68481a33100a49b7a9b1e6aa976de614
Source dataset
uspto-grants-1990_08
Patent number
US04948804

Reaction notes

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