Sodium Bicarbonate → HCID 178468139, compound

HRID 1709195Notes

Reaction equation

HRID 1709195 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][CH2:10][O:11][CH2:12][CH3:13])=[CH:4][CH:3]=1.[NH:14]([C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1)[C:15]([NH2:17])=[NH:16].[C:27]([O-:30])([OH:29])=[O:28].[Na+]>N1C=CC=CC=1>[C:27](=[O:28])([OH:30])[OH:29].[NH:14]([C:18]1[CH:26]=[CH:25][C:21]([C:22]([O:1][C:2]2[CH:3]=[CH:4][C:5]([S:8][CH2:9][CH2:10][O:11][CH2:12][CH3:13])=[CH:6][CH:7]=2)=[O:23])=[CH:20][CH:19]=1)[C:15]([NH2:17])=[NH:16]

Participants

5

Reactant 3

HCID 516892Sodium BicarbonateHCID 150272734-[(2-Ethoxyethyl)thio]phenolHCID 178512519HCID 178512519, compound

Product 1

HCID 178468139HCID 178468139, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3.4 g of 2-ethoxyethyl 4-hydroxyphenyl sulfide was dissolved in 50 ml of pyridine. 4-Guanidinobenzoyl chloride was added to the solution under cooling with ice and the mixture was stirred at room temperature for 27 h. A saturated aqueous solution of sodium hydrocarbonate was added thereto under cooling with ice. A precipitate thus formed was recovered by filtration, washed with water and then with acetone, and dried to obtain 2.86 g (yield: 40 %) of 4-(2-ethoxyethylthio)phenyl 4-guanidinobenzoate carbonate.

Workup

  1. temperatureunder cooling with ice
  2. temperatureunder cooling with ice
  3. customA precipitate thus formed
  4. filtrationwas recovered by filtration
  5. washwashed with water
  6. dry with materialwith acetone, and dried

Sources & evidence

ORD record
ord-6cef8c273965478ab65e9f151f671b83
Source dataset
uspto-grants-1990_08
Patent number
US04948808

Reaction notes

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