4-Methylmorpholine → Ethyl 2-(3-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl](methyl)amino}azetidin-1-yl)-4-methyl-1,3-thiazole-5-carboxylate

HRID 170924Notes

Reaction equation

HRID 170924 reaction equation
[CH3:1][c:2]1[n:3][c:4]([N:12]2[CH2:13][CH:14]([NH:16][CH3:17])[CH2:15]2)[s:5][c:6]1[C:7](=[O:8])[O:9][CH2:10][CH3:11].[CH3:39][N:40]1[CH2:41][CH2:42][O:43][CH2:44][CH2:45]1.[Cl:18][c:19]1[n:20][c:21]([C:26](=[O:27])[OH:28])[nH:22][c:23]1[CH2:24][CH3:25].[OH:29][n:30]1[c:31]2[cH:32][cH:33][cH:34][cH:35][c:36]2[n:37][n:38]1>>[CH3:1][c:2]1[n:3][c:4]([N:12]2[CH2:13][CH:14]([N:16]([CH3:17])[C:26]([c:21]3[n:20][c:19]([Cl:18])[c:23]([CH2:24][CH3:25])[nH:22]3)=[O:28])[CH2:15]2)[s:5][c:6]1[C:7](=[O:8])[O:9][CH2:10][CH3:11]

Participants

5

Reactant 4

HCID 79724-MethylmorpholineHCID 757711-HydroxybenzotriazoleHCID 67548189Ethyl 4-methyl-2-[3-(methylamino)azetidin-1-yl]-1,3-thiazole-5-carboxylateHCID 675489294-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

Product 1

HCID 67549142Ethyl 2-(3-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl](methyl)amino}azetidin-1-yl)-4-methyl-1,3-thiazole-5-carboxylate

Sources & evidence

ORD record
ord-64a22053f37649d086b5b9ac364c29eb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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