反应详情

To 1.5 g of 1-t-butoxycarbonyl-4-[3-(2-furyl)propyl]-piperazine was added 5 ml of trifluoroacetic acid under ice-cooling, and the resultant mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, and then dissolved in ethyl acetate 10 ml. To the solution was added 4N hydrochloric acid-dioxane solution under ice-cooling to yield 1.3 g of 1-[3-(2-furyl)propyl]piperazine.2 hydrochloride.

1. temperaturecooling
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. dissolutiondissolved in ethyl acetate 10 ml
4. additionTo the solution was added 4N hydrochloric acid-dioxane solution under ice-
5. temperaturecooling