Hydrochloric Acid → HCID 13826152, compound

HRID 1709293Notes

Reaction equation

HRID 1709293 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:16])[CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[CH:6][CH:5]=1.Cl.[CH2:18](O)[CH3:19]>>[NH2:1][CH2:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([C:10](=[O:16])[CH2:11][CH2:12][C:13]([O:15][CH2:18][CH3:19])=[O:14])=[CH:8][CH:9]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 13673553HCID 13673553, compound

Product 1

HCID 13826152HCID 13826152, compound

Procedure

On to a mixture of 127.2 g. (0.49 mole) of the acid obtained according to (b) and 800 ml. ethanol is passed, while stirring, gaseous hydrogen chloride and the reaction mixture is heated to reflux temperature for 2 hours, whereafter it is then strongly cooled. The precipitated crystals are filtered off with suction, washed with cold ethanol and dried over anhydrous calcium chloride. Yield 137.1 g. (97% of theory) of hydrochloride; m.p. 162°-165° C.

Workup

  1. temperatureto reflux temperature for 2 hours
  2. temperaturewhereafter it is then strongly cooled
  3. filtrationThe precipitated crystals are filtered off with suction
  4. washwashed with cold ethanol
  5. dry with materialdried over anhydrous calcium chloride

Sources & evidence

ORD record
ord-69c0790048324e9c84662ff09c89dd05
Source dataset
uspto-grants-1990_08
Patent number
US04948809

Reaction notes

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