Sodium Hydroxide → HCID 13826078, compound

HRID 1709294Notes

Reaction equation

HRID 1709294 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([NH:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:28])[CH2:21][CH2:22][C:23]([O:25]CC)=[O:24])=[CH:16][CH:15]=2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([NH:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:28])[CH2:21][CH2:22][C:23]([OH:25])=[O:24])=[CH:16][CH:15]=2)(=[O:9])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13826077HCID 13826077, compound

Product 1

HCID 13826078HCID 13826078, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 5.0 g. (11.8 mmole) of the product obtained according to (d), 18 ml. 2N aqueous sodium hydroxide solution and 20 ml. methanol is stirred for 3 hours at 50° C. The methanol is then distilled off in a vacuum and the aqueous solution is extracted with diethyl ether. Subsequently, it is acidified with 6N hydrochloric acid and the precipitated acid is filtered off with suction, washed with water and dried over potassium hydroxide. Yield 4.6 g. (quantitative); m.p. 126°-128° C.

Workup

  1. distillationThe methanol is then distilled off in a vacuum
  2. extractionthe aqueous solution is extracted with diethyl ether
  3. filtrationthe precipitated acid is filtered off with suction
  4. washwashed with water
  5. dry with materialdried over potassium hydroxide

Sources & evidence

ORD record
ord-75515e4b2f4f4ea88c37ffe0df35148e
Source dataset
uspto-grants-1990_08
Patent number
US04948809

Reaction notes

Loading…