Sodium Hydroxide → HCID 13826078, compound

Participants

Reaction Steps

A mixture of 5.0 g. (11.8 mmole) of the product obtained according to (d), 18 ml. 2N aqueous sodium hydroxide solution and 20 ml. methanol is stirred for 3 hours at 50° C. The methanol is then distilled off in a vacuum and the aqueous solution is extracted with diethyl ether. Subsequently, it is acidified with 6N hydrochloric acid and the precipitated acid is filtered off with suction, washed with water and dried over potassium hydroxide. Yield 4.6 g. (quantitative); m.p. 126°-128° C.

Provenance & Evidence