Hydrochloric Acid → HCID 178481944, compound

HRID 1709317Notes

Reaction equation

HRID 1709317 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3](N)=[CH:4][C:5](OC)=[O:6].[CH3:12][NH:13][NH2:14].Cl>O>[CH3:12][N:13]1[C:3]([C:2]([F:11])([F:10])[F:1])=[CH:4][C:5]([OH:6])=[N:14]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6061MethylhydrazineHCID 53421320Methyl 4,4,4-trifluoro-3-amino-2-butenoate

Product 1

HCID 178481944HCID 178481944, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 33.82 g (0.20 mole) of methyl 4,4,4-trifluoro-3-amino-2-butenoate and 10.1 g (0.22 mole) of methylhydrazine was heated at 50° C. for 22.25 hr. The mixture was then cooled, and 15 ml. of water and about 12 ml. of conc. hydrochloric acid were added to bring the pH of the mixture to 6.5-7.0. The precipitated product was filtered off and dried to obtain 25.26 g (76% yield) of the product m.p. 130.5°-131° C.

Workup

  1. temperatureThe mixture was then cooled
  2. filtrationThe precipitated product was filtered off
  3. customdried

Sources & evidence

ORD record
ord-5110cc36049a426996243af7fa81a977
Source dataset
uspto-grants-1990_08
Patent number
US04948902

Reaction notes

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