Hydrochloric Acid → HCID 19804760, compound

HRID 1709341Notes

Reaction equation

HRID 1709341 reaction equation
[Cl:1][C:2]1[C:11]([CH2:12][C:13]#[N:14])=[C:10]([S:15]([CH3:18])(=[O:17])=[O:16])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[C:11]([CH2:12][C:13]#[N:14])=[C:10]([S:15]([CH3:18])(=[O:17])=[O:16])[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19804726HCID 19804726, compound

Product 1

HCID 19804760HCID 19804760, compoundYield 23.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To 4.0 g of methyl 2-chloro-3-cyanomethyl-4-methanesulfonylbenzoate and 50 ml of methanol, 5 ml of an aqueous solution containing 0.72 g of sodium hydroxide (93%) was gradually added. The mixture was stirred for 15 minutes at room temperature. Then, the reaction mixture was neutralized with diluted hydrochloric acid, methanol was distilled off under reduced pressure and the concentrated solution was extracted with chloroform. After washing the extract with water and drying it, chloroform was distilled off to obtain 0.9 g of the desired product. Melting point: 169°-172° C.

Workup

  1. additionwas gradually added
  2. distillationwas distilled off under reduced pressure
  3. extractionthe concentrated solution was extracted with chloroform
  4. washAfter washing the
  5. extractionextract with water
  6. dry with materialdrying it, chloroform
  7. distillationwas distilled off

Sources & evidence

ORD record
ord-2a3e30c8a216431b83d2942dcb78f995
Source dataset
uspto-grants-1990_08
Patent number
US04948887

Reaction notes

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