Sodium Acetate → HCID 19804727, compound

HRID 1709342Notes

Reaction equation

HRID 1709342 reaction equation
Br[CH2:2][C:3]1[C:4]([Cl:17])=[C:5]([CH:10]=[CH:11][C:12]=1[S:13]([CH3:16])(=[O:15])=[O:14])[C:6]([O:8][CH3:9])=[O:7].[C:18]([O-:21])(=[O:20])[CH3:19].[Na+]>CN(C=O)C>[C:18]([O:21][CH2:2][C:3]1[C:4]([Cl:17])=[C:5]([CH:10]=[CH:11][C:12]=1[S:13]([CH3:16])(=[O:15])=[O:14])[C:6]([O:8][CH3:9])=[O:7])(=[O:20])[CH3:19]

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 10969914Methyl 3-bromomethyl-2-chloro-4-methylsulfonylbenzoate

Product 1

HCID 19804727HCID 19804727, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

50 ml of a DMF solution containing 5.0 g of methyl 3-bromomethyl-2-chloro-4-methanesulfonylbenzoate and 1.2 g of sodium acetate, was stirred for 2 hours at 100° C. After cooling, the reaction mixture was poured into ice water and extracted with chloroform. After washing the extract with water and drying it, the solvent was distilled off to obtain 4.2 g of the desired product. Melting point: 165°-168° C.

Workup

  1. temperatureAfter cooling
  2. extractionextracted with chloroform
  3. washAfter washing the
  4. extractionextract with water
  5. customdrying it
  6. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-3865fa499cc44c0c8d5d30c43715f349
Source dataset
uspto-grants-1990_08
Patent number
US04948887

Reaction notes

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