Hydrochloric Acid → HCID 23037407, compound

HRID 1709440Notes

Reaction equation

HRID 1709440 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16]([CH2:17][C:18]([NH:20][CH2:21][CH2:22][N:23]([CH3:25])[CH3:24])=[O:19])[C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.Cl>CC(C)=O>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16]([CH2:17][C:18]([NH:20][CH2:21][CH2:22][N:23]([CH3:25])[CH3:24])=[O:19])[C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14390214HCID 14390214, compound

Product 1

HCID 23037407HCID 23037407, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-(4-Chlorophenyl)-N-[2-(dimethylamino)ethyl]-3H-imidazo[4,5-b]pyridine-3-acetamide (0.5 g, 0.0014 mole) was dissolved in acetone, acidified with ethanolic hydrogen chloride, and seeded to initiate crystallization. The solid was collected by filtration, washed with diethyl ether, and dried under high vacuum at room temperature overnight to give 0.60 g (quantitative yield), m.p. 222°-25° C.

Workup

  1. customcrystallization
  2. filtrationThe solid was collected by filtration
  3. washwashed with diethyl ether
  4. customdried under high vacuum at room temperature overnight
  5. customto give 0.60 g (quantitative yield), m.p. 222°-25° C.

Sources & evidence

ORD record
ord-6a73c7ad7f2a4dadb1d6d7dab436946f
Source dataset
uspto-grants-1990_08
Patent number
US04948800

Reaction notes

Loading…