Methyl Isocyanate → HCID 14855877, compound

HRID 1709644Notes

Reaction equation

HRID 1709644 reaction equation
[F:1][C:2]([F:17])=[CH:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([NH:15][NH2:16])=[O:14].[CH3:18][N:19]=[C:20]=[O:21]>C(OCC)C>[CH3:18][NH:19][C:20]([NH:16][NH:15][C:13](=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH:3]=[C:2]([F:17])[F:1])=[O:21]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 14855875HCID 14855875, compound

Product 1

HCID 14855877HCID 14855877, compoundYield 81.9%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A stirred solution of 0.5 gram (0.002 mole) of 12,12-difluoro-11-dodecenoic acid hydrazide and 0.11 gram (0.002 mole) of methyl isocyanate in 30 ml of diethyl ether was heated under reflux for three hours. The reaction mixture was concentrated under reduced pressure yielding 0.5 gram of N-methyl-2-(12,12-difluoro-11-dodecenoyl)hydrazinecarboxamide. The nmr spectrum was consistent with the proposed structure.

Workup

  1. temperatureunder reflux for three hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-2993282317104f3db0f717d6c3caf27c
Source dataset
uspto-grants-1990_08
Patent number
US04950666

Reaction notes

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