Sodium Hypochlorite → HCID 178506304, compound

HRID 1709700Notes

Reaction equation

HRID 1709700 reaction equation
[Cl:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[CH:3]=1.[O-][Cl:12].[Na+]>CO>[Cl:12][C:3]1[C:4]([C:7]([F:10])([F:9])[F:8])=[N:5][NH:6][C:2]=1[Cl:1]

Participants

4

Reactant 2

HCID 23665760Sodium HypochloriteHCID 1785061975-chloro-3-(trifluoromethyl)-1H-pyrazole

Product 1

HCID 178506304HCID 178506304, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 5-chloro-3-trifluoromethylpyrazole (190.0 g, 1.11 mol) in 400 ml of methanol is treated with liquid bleach (5.25% NaOCl) for 3 hr. The reaction mixture is then extracted with ether, the combined ether extracts are acidified with HCl (300 ml), washed with brine, dried and concentrated to give 4,5-dichloro-3-trifluoromethylpyrazole, a light yellow solid, m.p. 58°-60° .

Workup

  1. extractionThe reaction mixture is then extracted with ether
  2. washwashed with brine
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-955e6731d4834cf980e08587bfdc5f65
Source dataset
uspto-grants-1990_08
Patent number
US04950678

Reaction notes

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