Hydrogen Peroxide → HCID 13914039, compound

HRID 1709704Notes

Reaction equation

HRID 1709704 reaction equation
[CH:1]([S:4][C:5]1[S:6][CH:7]=[C:8]([O:10][S:11]([CH3:14])(=[O:13])=[O:12])[N:9]=1)([CH3:3])[CH3:2].OO.[OH2:17].[OH-:18].[Na+]>C(O)(=O)C>[CH:1]([S:4]([C:5]1[S:6][CH:7]=[C:8]([O:10][S:11]([CH3:14])(=[O:12])=[O:13])[N:9]=1)(=[O:18])=[O:17])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 14798Sodium HydroxideHCID 13914034HCID 13914034, compound

Product 1

HCID 13914039HCID 13914039, compoundYield 88.7%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2.5 g of 2-isopropylthio-4-methylsulfonyloxy-1,3-thiazole was dissolved in 10 ml of acetic acid. 2.9 ml of 35% aqueous hydrogen peroxide was added to the solution and the reaction was continued at 70° to 80° C. for 2 hours. The reaction mixture was poured into cold water and neutralized with 5% aqueous sodium hydroxide. The neutral solution was extracted by ethyl acetate and washed with saturated aqueous solution of common salt, followed by drying over anhydrous sodium sulfate to be concentrated to 2.5 g of a white crystal of the objective compound (yield: 88.7%).

Workup

  1. extractionThe neutral solution was extracted by ethyl acetate
  2. washwashed with saturated aqueous solution of common salt
  3. dry with materialby drying over anhydrous sodium sulfate

Sources & evidence

ORD record
ord-ea811f277c9a48469fc59229fb048493
Source dataset
uspto-grants-1990_08
Patent number
US04950679

Reaction notes

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