Benzoic Acid → 1-Phenyl-1-propanone

HRID 1709733Notes

Reaction equation

HRID 1709733 reaction equation
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10](O)(=O)[CH2:11]C>O>[C:1]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)(=[O:9])[CH2:10][CH3:11]

Participants

4

Reactant 2

HCID 243Benzoic AcidHCID 1032Propionic Acid

Product 1

HCID 71481-Phenyl-1-propanone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 16 g/h of benzoic acid, 57 g/h of propionic acid and 14.5 g/h of water was evaporated in an evaporator and passed, together with 10 l/h of nitrogen, at 400° C., over 100 ml of a catalyst which contained 2.5% by weight of sodium oxide, the remainder being anatase. The reaction gases were then cooled and were collected in a receiver. From the discharged two-phase mixture, the organic phase was analyzed by gas chromatography. The conversion of both carboxylic acids was 100%. The selectivity with respect to propiophenone was 99%.

Workup

  1. customwas evaporated in an evaporator
  2. custompassed, together with 10 l/h of nitrogen, at 400° C., over 100 ml of a catalyst which
  3. customThe reaction gases
  4. temperaturewere then cooled
  5. customwere collected in a receiver

Sources & evidence

ORD record
ord-850fbe7ba64a467aa422ae8db35bba73
Source dataset
uspto-grants-1990_08
Patent number
US04950763

Reaction notes

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