Benzoic Acid → Cyclohexyl phenyl ketone

HRID 1709734Notes

Reaction equation

HRID 1709734 reaction equation
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:10]1(C(O)=O)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>O>[C:10]1([C:1]([CH:2]2[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]2)=[O:9])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 243Benzoic AcidHCID 7413Cyclohexanecarboxylic acid

Product 1

HCID 12837Cyclohexyl phenyl ketone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 11.5 g/h of benzoic acid, 36 g/h of cyclohexanecarboxylic acid and 13 g/h of water was evaporated in an evaporator and passed, together with 10 l/h of nitrogen, at 450° C., over 100 ml of a catalyst which contained 2% by weight of potassium oxide, the remainder being anatase. The reaction gases were then cooled and were collected in a receiver. From the discharged two-phase mixture, the organic phase was analyzed by gas chromatography. The conversion of benzoic acid was 98%. The selectivity with respect to cyclohexyl phenyl ketone was 60%.

Workup

  1. customwas evaporated in an evaporator
  2. custompassed, together with 10 l/h of nitrogen, at 450° C., over 100 ml of a catalyst which
  3. customThe reaction gases
  4. temperaturewere then cooled
  5. customwere collected in a receiver

Sources & evidence

ORD record
ord-48466fdd9a864c38b24c54daee5fdb40
Source dataset
uspto-grants-1990_08
Patent number
US04950763

Reaction notes

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