Acetic Acid → 3-Acetylpyridine

A mixture of 22 g/h of methyl nicotinate, 57 g/h of acetic acid and 20 g/h of water was evaporated in an evaporator and passed, together with 10 l/h of nitrogen, at 400° C., over 100 ml of catalyst E, which contained 2% by weight of sodium oxide, the remainder being anatase. The catalyst was prepared similarly to Example 8, by impregnating 980 g of TiO2 carrier I with a solution which contained 20 g of Na2O (as aqueous NaOH). The reaction gases were then cooled and were collected in a receiver. From the discharged two-phase mixture, the organic phase was analyzed by gas chromatography. The conversion of nicotinic ester and of acetic acid was 100% in each case. The selectivity with respect to 3-acetylpyridine was 60%. In addition, pyridine was formed with a selectivity of 29%.

1. customwas evaporated in an evaporator
2. custompassed, together with 10 l/h of nitrogen, at 400° C., over 100 ml of catalyst E, which
3. customThe catalyst was prepared similarly to Example 8
4. customThe reaction gases
5. temperaturewere then cooled
6. customwere collected in a receiver
7. customIn addition, pyridine was formed with a selectivity of 29%

ORD record

ord-7094a2ad2b304387a67469d3c673cb4d

Source dataset

uspto-grants-1990_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04950763