Dichloromethane → HCID 23036526, compound

HRID 1709760Notes

Reaction equation

HRID 1709760 reaction equation
[CH2:1]([O:3][C:4]([CH3:31])([CH3:30])[CH2:5][S:6][CH2:7][C:8]1[C:13]([CH3:14])=[C:12]([O:15][CH3:16])[CH:11]=[CH:10][N+:9]=1[C:17]1[NH:18][C:19]2[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:20]=2[N:21]=1)[CH3:2].C(Cl)[Cl:33]>Cl>[Cl-:33].[CH2:1]([O:3][C:4]([CH3:30])([CH3:31])[CH2:5][S:6][CH2:7][C:8]1[C:13]([CH3:14])=[C:12]([O:15][CH3:16])[CH:11]=[CH:10][N+:9]=1[C:17]1[NH:18][C:19]2[CH:25]=[C:24]([C:26]([F:28])([F:27])[F:29])[CH:23]=[CH:22][C:20]=2[N:21]=1)[CH3:2]

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 23036497HCID 23036497, compound

Product 1

HCID 23036526HCID 23036526, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

450 mg of intramolecularly deprotonized 2-[[(2-ethoxy-2-methylpropyl)thio]methyl]-4-methoxy-3-methyl-1-[5-(trifluoromethyl)-2-benzimidazolyl]pyridinium cation were dissolved in methylene chloride, whereupon 2 ml of 4.7N methanolic hydrochloric acid were added thereto, the solution was concentrated and the residue was crystallized from ether. The 2-[[(2-ethoxy-2-methylpropyl)thio]methyl]-4-methoxy-3-methyl-1-[5-(trifluoromethyl)-2-benzimidazolyl]pyridinium chloride obtained exhibited a melting point of 119°-120°.

Workup

  1. additionwere added
  2. concentrationthe solution was concentrated
  3. customthe residue was crystallized from ether

Sources & evidence

ORD record
ord-92cc8b1acd304d898fb72beead3626f6
Source dataset
uspto-grants-1990_08
Patent number
US04950677

Reaction notes

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