Methanesulfonic Acid → HCID 23036494, compound

HRID 1709761Notes

Reaction equation

HRID 1709761 reaction equation
[OH:1][CH2:2][CH2:3][O:4][C:5]([CH3:32])([CH3:31])[CH2:6][S:7][CH2:8][C:9]1[C:14]([CH3:15])=[C:13]([O:16][CH3:17])[CH:12]=[CH:11][N+:10]=1[C:18]1[NH:19][C:20]2[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:21]=2[N:22]=1.[CH3:33][S:34]([OH:37])(=[O:36])=[O:35]>CO>[CH3:33][S:34]([O-:37])(=[O:36])=[O:35].[OH:1][CH2:2][CH2:3][O:4][C:5]([CH3:32])([CH3:31])[CH2:6][S:7][CH2:8][C:9]1[C:14]([CH3:15])=[C:13]([O:16][CH3:17])[CH:12]=[CH:11][N+:10]=1[C:18]1[NH:19][C:20]2[CH:26]=[C:25]([C:27]([F:28])([F:30])[F:29])[CH:24]=[CH:23][C:21]=2[N:22]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 23036495HCID 23036495, compound

Product 1

HCID 23036494HCID 23036494, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

370 mg of intramolecularly deprotonized 2-[[[2-(2-hydroxyethoxy)-2-methylpropyl]thio]methyl]-4-methoxy-3-methyl-1-[5-(trifluoromethyl)-2-benzimdazolyl]pyridinium cation were dissolved in methanol, whereupon 100 mg of methanesulfonic acid were added thereto, the solution was concentrated and the residue was crystallized from ether/ethyl acetate. The 2-[[[2-(2-hydroxyethoxy)-2-methylpropyl]thio]methyl]-4-methoxy-3-methyl-1-[5-(trifluoromethyl)-2-benzimidazolyl]pyridinium methanesulfonate obtained exhibited a melting point of 105°-107° (decomposition).

Workup

  1. additionwere added
  2. concentrationthe solution was concentrated
  3. customthe residue was crystallized from ether/ethyl acetate

Sources & evidence

ORD record
ord-1f6903b1d8a34fb398f40356dcf064d8
Source dataset
uspto-grants-1990_08
Patent number
US04950677

Reaction notes

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