Methanesulfonic Acid → HCID 23036501, compound

HRID 1709762Notes

Reaction equation

HRID 1709762 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N+:6]([C:9]2[NH:10][C:11]3[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:12]=3[N:13]=2)=[C:5]([CH2:22][S:23][CH2:24][C:25]([O:28][CH2:29][CH2:30][O:31][CH3:32])([CH3:27])[CH3:26])[C:4]=1[CH3:33].[CH3:34][S:35]([OH:38])(=[O:37])=[O:36]>CO>[CH3:34][S:35]([O-:38])(=[O:37])=[O:36].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N+:6]([C:9]2[NH:10][C:11]3[CH:17]=[C:16]([C:18]([F:20])([F:19])[F:21])[CH:15]=[CH:14][C:12]=3[N:13]=2)=[C:5]([CH2:22][S:23][CH2:24][C:25]([O:28][CH2:29][CH2:30][O:31][CH3:32])([CH3:27])[CH3:26])[C:4]=1[CH3:33]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 23036502HCID 23036502, compound

Product 1

HCID 23036501HCID 23036501, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

483.5 mg of intramolecularly deprotonized 4-methoxy-2-[[[2-(2-methoxyethoxy)-2-methylpropyl]thio]methyl]-3-methyl-1-[5-(trifluoromethyl)-2-benzimidazolyl]pyridinium cation were dissolved in 5 ml of methanol, whereupon 96 mg of methanesulfonic acid were added thereto, the solution was concentrated and the residue was dissolved several times in ethyl acetate and the solution was concentrated each time. The resinous residue was dried in a high vacuum, whereby 4-methoxy-2-[[[2-(2-methoxyethoxy)-2-methylpropyl]thio]methyl]-3-methyl-1-[5-(trifluoromethyl)-2-benzimidazolyl]-pyridinium methanesulfonate was obtained as a foam. The microanalysis showed the following values:

Workup

  1. additionwere added
  2. concentrationthe solution was concentrated
  3. dissolutionthe residue was dissolved several times in ethyl acetate
  4. concentrationthe solution was concentrated each time
  5. customThe resinous residue was dried in a high vacuum

Sources & evidence

ORD record
ord-14975dd9978745eaa04ff8fcb5545ed4
Source dataset
uspto-grants-1990_08
Patent number
US04950677

Reaction notes

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