Dichloromethane → HCID 23036492, compound

HRID 1709764Notes

Reaction equation

HRID 1709764 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N+:6]([C:9]2[NH:10][C:11]3[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:12]=3[N:13]=2)=[C:5]([CH2:22][S:23][CH:24]=[C:25]([CH3:27])[CH3:26])[C:4]=1[CH3:28].C(Cl)[Cl:30]>Cl>[Cl-:30].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N+:6]([C:9]2[NH:10][C:11]3[CH:17]=[C:16]([C:18]([F:20])([F:21])[F:19])[CH:15]=[CH:14][C:12]=3[N:13]=2)=[C:5]([CH2:22][S:23][CH:24]=[C:25]([CH3:26])[CH3:27])[C:4]=1[CH3:28]

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 23036493HCID 23036493, compound

Product 1

HCID 23036492HCID 23036492, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

60 mg of intramolecularly deprotonized 4-methoxy 3-methyl-2-[[(2-methylpropenyl)thio]methyl]-1-[5-(trifluoromethyl)-2-benzimidazolyl]pyridinium cation were dissolved in methylene chloride, whereupon 0.5 ml of 4.7N methanolic hydrochloric acid was added thereto, the solution was concentrated and the residue was crystallized from ethyl acetate/ether. The 4-methoxy-3-methyl-2-[[(2-methylpropenyl)thio]methyl]-1-[5-(trifluoromethyl)-2-benzimidazolyl]pyridinium chloride obtained exhibited a melting point of 142°-144°.

Workup

  1. additionwas added
  2. concentrationthe solution was concentrated
  3. customthe residue was crystallized from ethyl acetate/ether

Sources & evidence

ORD record
ord-bc53d3004b224a56a46c436050a41199
Source dataset
uspto-grants-1990_08
Patent number
US04950677

Reaction notes

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