Dimethyl Sulfoxide → HCID 14324454, compound

HRID 1709792Notes

Reaction equation

HRID 1709792 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[OH:15][C:16]1[CH:20]=[C:19]([CH3:21])[O:18][N:17]=1.C(=O)([O-])O.[Na+].CS(C)=O>O>[CH3:21][C:19]1[O:18][N:17]([C:2]2[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=2[N+:12]([O-:14])=[O:13])[C:16](=[O:15])[CH:20]=1

Participants

6

Reactant 4

HCID 679Dimethyl SulfoxideHCID 84624-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotolueneHCID 24781HymexazolHCID 516892Sodium Bicarbonate

Product 1

HCID 14324454HCID 14324454, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

226 g of 4-chloro-3-nitrobenzotrifluoride, 129 g of 3-hydroxy-5-methylisoxazole, 336 g of sodium hydrogen carbonate, and 600 ml of dimethylsulfoxide were mixed with each other and reacted at 75° C. for 6 hours. After completion of the reaction, the reaction solution was poured into water, and the crystals which precipitated were purified using a silica gel short column chromatography and recrystallized from water-methanol.

Workup

  1. customreacted at 75° C. for 6 hours
  2. customAfter completion of the reaction
  3. customthe crystals which precipitated
  4. customwere purified
  5. customrecrystallized from water-methanol

Sources & evidence

ORD record
ord-c908a10a6a5f4f96959780160f281820
Source dataset
uspto-grants-1990_08
Patent number
US04950764

Reaction notes

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