Potassium Iodide → HCID 14407071, compound

HRID 1709885Notes

Reaction equation

HRID 1709885 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[OH:9])=[CH:4][CH:3]=1.Cl[CH2:24][CH2:25][CH2:26][O:27][C:28]1[CH:38]=[CH:37][C:31]2[CH:32]=[CH:33][C:34](=[O:36])[O:35][C:30]=2[CH:29]=1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>C(O)CCC>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=2)([OH:9])[CH:10]2[CH2:11][CH2:12][N:13]([CH2:24][CH2:25][CH2:26][O:27][C:28]3[CH:38]=[CH:37][C:31]4[CH:32]=[CH:33][C:34](=[O:36])[O:35][C:30]=4[CH:29]=3)[CH2:14][CH2:15]2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 19006662H-1-Benzopyran-2-one, 7-(3-chloropropoxy)-HCID 11208889Bis(4-fluorophenyl)(piperidin-4-yl)methanol

Product 1

HCID 14407071HCID 14407071, compoundYield 71.2%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

This compound was prepared according to the procedure of Example 1. A mixture of 3.0 g (0.01 mole) of α,α-bis(p-fluorophenyl)-4-piperidinemethanol, 2.4 g (0.01 mole of 7-(3-chloropropoxy)2H-1-benzopyran-2-one, 5.3 g (0.05 mole) of anhydrous sodium carbonate and 0.3 g of potassium iodide in 100 ml of 1-butanol gave 3.6 g (71%) of pale yellow crystals, m.p. 99°-120° C. with decomposition.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-4c783a4d413d42b989375c749119b846
Source dataset
uspto-grants-1990_08
Patent number
US04950674

Reaction notes

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