Potassium Iodide → HCID 23036426, compound

HRID 1709928Notes

Reaction equation

HRID 1709928 reaction equation
[C:1](O)(=O)[C:2](O)=[O:3].C1(C(C2C=CC=CC=2)=C2CCN([CH2:20][CH2:21][CH2:22][O:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)CC2)C=CC=CC=1.[F:36][C:37]1[CH:42]=[CH:41][C:40]([C:43]([C:51]2[CH:56]=[CH:55][C:54]([F:57])=[CH:53][CH:52]=2)([CH:45]2[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]2)[OH:44])=[CH:39][CH:38]=1.ClCCCOC1C=CC=CC=1OCC.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>C(O)CCC>[CH2:2]([O:3][C:27]1[CH:26]=[CH:25][C:24]([O:23][CH2:22][CH2:21][CH2:20][N:48]2[CH2:47][CH2:46][CH:45]([C:43]([C:51]3[CH:52]=[CH:53][C:54]([F:57])=[CH:55][CH:56]=3)([C:40]3[CH:41]=[CH:42][C:37]([F:36])=[CH:38][CH:39]=3)[OH:44])[CH2:50][CH2:49]2)=[CH:29][CH:28]=1)[CH3:1]

Participants

7

Reactant 5

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 11208889Bis(4-fluorophenyl)(piperidin-4-yl)methanolHCID 12760310HCID 12760310, compoundHCID 230363354-(Diphenylmethylene)-1-(3-phenoxypropyl)piperidine oxalate

Product 1

HCID 23036426HCID 23036426, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 1. A mixture of 3.0 g (0.01 mole) of [α,α-bis(4-fluorophenyl)]-4-piperidinemethanol, 2.1 g (0.01 mole) of 1-chloro-3-(2-ethoxyphenoxy)propane, 3.7 g (0.035 mole) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 ml of 1-butanol gave 3.6 g (75%) of the title compound as an off-white solid, mp 89°-91° C. (petroleum ether, 60°-110° C.). Analysis: Calculated for C29H33F2NO3 : C, 72.33; H, 6.91; N, 2.91. Found: C, 72.39; H, 6.90; N, 2.96.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-7530410661734271b100c631ec5ef62a
Source dataset
uspto-grants-1990_08
Patent number
US04950674

Reaction notes

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