Potassium Iodide → HCID 23036426, compound

Participants

Reaction Steps

This compound was prepared according to the procedure used to synthesize the compound of Example 1. A mixture of 3.0 g (0.01 mole) of [α,α-bis(4-fluorophenyl)]-4-piperidinemethanol, 2.1 g (0.01 mole) of 1-chloro-3-(2-ethoxyphenoxy)propane, 3.7 g (0.035 mole) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 ml of 1-butanol gave 3.6 g (75%) of the title compound as an off-white solid, mp 89°-91° C. (petroleum ether, 60°-110° C.). Analysis: Calculated for C29H33F2NO3 : C, 72.33; H, 6.91; N, 2.91. Found: C, 72.39; H, 6.90; N, 2.96.

Provenance & Evidence