Hydrochloric Acid → HCID 131716522, compound

HRID 1709964Notes

Reaction equation

[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([NH:12][CH2:13][C:14]([NH:16][C@H:17]([C:22]([NH:24][C@H:25]([C:31]([OH:33])=[O:32])[CH2:26][CH2:27][C:28](=[O:30])[NH2:29])=[O:23])[CH2:18][CH:19]([CH3:21])[CH3:20])=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>>[NH2:1][C@H:2]([C:10]([NH:12][CH2:13][C:14]([NH:16][C@H:17]([C:22]([NH:24][C@H:25]([C:31]([OH:33])=[O:32])[CH2:26][CH2:27][C:28](=[O:30])[NH2:29])=[O:23])[CH2:18][CH:19]([CH3:21])[CH3:20])=[O:15])=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid2×

HCID 131716521HCID 131716521, compound

Product 1

HCID 131716522HCID 131716522, compound

Procedure

Boc-Phe-Gly-Leu-Gln-NA (0.90 g) was deblocked by treatment with ethanolic HCl to yield 0.79 g of H-Phe-Gly-Leu-Gln-NA HCl. TLC in 1-butanol:acetic acid:water (4:1:1) indicated a major spot, Rf 0.61, and two trace spots, Rf 0.71 and Rf 0.51.

Sources & evidence

ORD record: ord-0f9be3a8b1af4633a7e987472a13c348
Source dataset: uspto-grants-1990_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04952493

Reaction notes

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