HCID 15055922, compound → HCID 23035313, compound

HRID 1709986Notes

Reaction equation

HRID 1709986 reaction equation
[OH:1][C:2]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[CH:14][C:3]=1[C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)=[O:5].Br[CH2:25][CH2:26][CH2:27][CH2:28][C:29]([NH2:31])=[O:30]>>[C:29]([CH2:28][CH2:27][CH2:26][CH2:25][O:1][C:2]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]([F:23])([F:21])[F:22])=[CH:14][C:3]=1[C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)=[O:5])(=[O:30])[NH2:31]

Participants

3

Reactant 2

HCID 15055922HCID 15055922, compoundHCID 15101532HCID 15101532, compound

Product 1

HCID 23035313HCID 23035313, compoundYield 66.9%

Procedure

Using the general method of Example I Part A, 4.7 g (0.014 mole) of 2-hydroxy-N-(2-pyridylmethyl)-5-(2,2,2-trifluoroethoxy)benzamide was reacted with 2.3 g (0.013 mole) of 5-bromovaleramide to give 3.7 g of white powdery 2-(4-carbamoylbutoxy)-N-(2-pyridylmethyl)-5-(2,2,2-trifluoroethoxy)benzamide, m.p. 178°-180° C. Analysis: Calculated for C20H22F3N3O4 : %C, 56.5; %H, 5.2; %N, 9.9; Found: %C, 56.7; %H, 5.2; %N, 9.9.

Sources & evidence

ORD record
ord-9d20963f3a324e70a2947abd554a4a72
Source dataset
uspto-grants-1990_08
Patent number
US04952574

Reaction notes

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