Ethyl 5-bromovalerate → HCID 69009437, compound

HRID 1709987Notes

Reaction equation

HRID 1709987 reaction equation
O[C:2]1[CH:3]=[CH:4][C:5]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[C:6]([CH:17]=1)[C:7]([NH:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)=[O:8].BrCCCCC(OCC)=O>>[N:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH2:10][NH:9][C:7](=[O:8])[C:6]1[CH:17]=[CH:2][CH:3]=[CH:4][C:5]=1[O:18][CH2:19][C:20]([F:22])([F:23])[F:21]

Participants

3

Reactant 2

HCID 84580Ethyl 5-bromovalerateHCID 130371785-Hydroxy-N-[(pyridin-2-yl)methyl]-2-(2,2,2-trifluoroethoxy)benzamide

Product 1

HCID 69009437HCID 69009437, compound

Procedure

Using the method of Example I Part A, 13.1 g (0.04 mole) of 5-hydroxy-N-(2-pyridylmethyl)-2-(2,2,2-trifluoroethoxy)benzamide was reacted with 11.7 g (0.056 mole) of ethyl 5-bromovalerate to give 13.7 g of white 5-(4-ethoxycarbonylbutoxy))-N-(2-pyridylmethyl)-2-(2,2,2-trifluoroethoxy)benzamide, m.p. 83°-84° C.

Sources & evidence

ORD record
ord-ed4502c1c1064096aac66bb9103b4df1
Source dataset
uspto-grants-1990_08
Patent number
US04952574

Reaction notes

Loading…