5-Hydroxy-N-[(pyridin-2-yl)methyl]-2-(2,2,2-trifluoroethoxy)benzamide → HCID 23035333, compound

HRID 1709988Notes

Reaction equation

HRID 1709988 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[C:6]([CH:17]=1)[C:7]([NH:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)=[O:8].Br[CH2:25][CH2:26][CH2:27][CH2:28][C:29]([NH2:31])=[O:30]>>[C:29]([CH2:28][CH2:27][CH2:26][CH2:25][O:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][CH2:19][C:20]([F:23])([F:21])[F:22])=[C:6]([CH:17]=1)[C:7]([NH:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)=[O:8])(=[O:30])[NH2:31]

Participants

3

Reactant 2

HCID 130371785-Hydroxy-N-[(pyridin-2-yl)methyl]-2-(2,2,2-trifluoroethoxy)benzamideHCID 15101532HCID 15101532, compound

Product 1

HCID 23035333HCID 23035333, compoundYield 45.7%

Procedure

Using the general method of Example I Part A, 6.5 g (0.02 mole) of 5-hydroxy-N-(2-pyridylmethyl)-2-(2,2,2-trifluoroethoxy)benzamide was reacted with 3.3 g (0.018 mole) of 5-bromovaleramide to give 3.5 g of white powdery 5-(4-carbamoylbutoxy)-N-(2-pyridylmethyl)-2-(2,2,2-trifluoroethoxy)benzamide, m.p.138°-139° C.

Sources & evidence

ORD record
ord-1c88ade2b74b474ba3bebd6660315501
Source dataset
uspto-grants-1990_08
Patent number
US04952574

Reaction notes

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