Ethyl bromoacetate → HCID 23035297, compound

HRID 1709989Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[C:6]([CH:17]=1)[C:7]([NH:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)=[O:8].Br[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27]>>[CH2:29]([O:28][C:26]([CH2:25][O:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][CH2:19][C:20]([F:23])([F:21])[F:22])=[C:6]([CH:17]=1)[C:7]([NH:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)=[O:8])=[O:27])[CH3:30]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 130371785-Hydroxy-N-[(pyridin-2-yl)methyl]-2-(2,2,2-trifluoroethoxy)benzamide

Product 1

HCID 23035297HCID 23035297, compound

Procedure

Using the general method of Example I Part A, 10.4 g (0.032 mole) of 5-hydroxy-N-(2-pyridylmethyl)-2-(2,2,2- trifluoroethoxy)benzamide was reacted with 7.45 g (0.045 mole) of ethyl bromoacetate to give 5.0 g of ivory powdery 5-(ethoxycarbonylmethoxy)-N-(2-pyridylmethyl)-2-(2,2,2- trifluoroethoxy)benzamide, m.p. 73°-76° C.

Sources & evidence

ORD record: ord-ee8e5160ee5a4fc3b446eaed99eaff86
Source dataset: uspto-grants-1990_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04952574

Reaction notes

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